Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model

Sandra Palus; Robert Schur; Yoshihiro J. Akashi; Barbara Bockmeyer; Rakesh Datta; Heather Halem; Jesse Dong; Michael D. Culler; Volker Adams; Stefan D. Anker; Jochen Springer

doi:10.1371/journal.pone.0026865

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Peer-reviewed

Research Article

Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model

Sandra Palus,

Affiliations Applied Cachexia Research, Department of Cardiology, Charité Medical School, Berlin, Germany, Center for Cardiovascular Research, Charité Medical School, Berlin, Germany
⨯
Robert Schur,

Affiliation Department of Cardiology, Heart Center Leipzig, University Leipzig, Leipzig, Germany
⨯
Yoshihiro J. Akashi,

Affiliations Applied Cachexia Research, Department of Cardiology, Charité Medical School, Berlin, Germany, Center for Cardiovascular Research, Charité Medical School, Berlin, Germany
⨯
Barbara Bockmeyer,

Affiliations Applied Cachexia Research, Department of Cardiology, Charité Medical School, Berlin, Germany, Center for Cardiovascular Research, Charité Medical School, Berlin, Germany
⨯
Rakesh Datta,

Affiliation IPSEN, Milford, Massachusetts, United States of America
⨯
Heather Halem,

Affiliation IPSEN, Milford, Massachusetts, United States of America
⨯
Jesse Dong,

Affiliation IPSEN, Milford, Massachusetts, United States of America
⨯
Michael D. Culler,

Affiliation IPSEN, Milford, Massachusetts, United States of America
⨯
Volker Adams,

Affiliation Department of Cardiology, Heart Center Leipzig, University Leipzig, Leipzig, Germany
⨯
Stefan D. Anker,

Affiliations Applied Cachexia Research, Department of Cardiology, Charité Medical School, Berlin, Germany, Centre for Clinical and Basic Research, IRCCS San Raffaele, Rome, Italy
⨯
Jochen Springer

* E-mail: jochen.springer@charite.de

Affiliations Applied Cachexia Research, Department of Cardiology, Charité Medical School, Berlin, Germany, Center for Cardiovascular Research, Charité Medical School, Berlin, Germany, Norwich Medical School, University of East Anglia, Norwich, United Kingdom
⨯

Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model

Sandra Palus,
Robert Schur,
Yoshihiro J. Akashi,
Barbara Bockmeyer,
Rakesh Datta,
Heather Halem,
Jesse Dong,
Michael D. Culler,
Volker Adams,
Stefan D. Anker

Published: November 15, 2011
https://doi.org/10.1371/journal.pone.0026865

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Ghrelin
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