Phosphoinositide 3-Kinaseγ Controls the Intracellular Localization of CpG to Limit DNA-PKcs-Dependent IL-10 Production in Macrophages

Kaoru Hazeki; Yukiko Kametani; Hiroki Murakami; Masami Uehara; Yuki Ishikawa; Kiyomi Nigorikawa; Shunsuke Takasuga; Takehiko Sasaki; Tsukasa Seya; Misako Matsumoto; Osamu Hazeki

doi:10.1371/journal.pone.0026836

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Open Access

Peer-reviewed

Research Article

Phosphoinositide 3-Kinaseγ Controls the Intracellular Localization of CpG to Limit DNA-PKcs-Dependent IL-10 Production in Macrophages

Kaoru Hazeki ,

* E-mail: khazeki@hiroshima-u.ac.jp

Affiliation Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
⨯
Yukiko Kametani,

Affiliation Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
⨯
Hiroki Murakami,

Affiliation Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
⨯
Masami Uehara,

Affiliation Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
⨯
Yuki Ishikawa,

Affiliation Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
⨯
Kiyomi Nigorikawa,

Affiliation Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
⨯
Shunsuke Takasuga,

Affiliation Department of Pathology and Immunology, Akita University School of Medicine, Akita, Japan
⨯
Takehiko Sasaki,

Affiliation Department of Pathology and Immunology, Akita University School of Medicine, Akita, Japan
⨯
Tsukasa Seya,

Affiliation Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Misako Matsumoto,

Affiliation Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Osamu Hazeki

Affiliation Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
⨯

Phosphoinositide 3-Kinaseγ Controls the Intracellular Localization of CpG to Limit DNA-PKcs-Dependent IL-10 Production in Macrophages

Kaoru Hazeki,
Yukiko Kametani,
Hiroki Murakami,
Masami Uehara,
Yuki Ishikawa,
Kiyomi Nigorikawa,
Shunsuke Takasuga,
Takehiko Sasaki,
Tsukasa Seya,
Misako Matsumoto

Published: October 28, 2011
https://doi.org/10.1371/journal.pone.0026836

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