Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy

Nahuai Badiola; Rita Machado de Oliveira; Federico Herrera; Cristina Guardia-Laguarta; Susana A. Gonçalves; Marta Pera; Marc Suárez-Calvet; Jordi Clarimon; Tiago Fleming Outeiro; Alberto Lleó

doi:10.1371/journal.pone.0026609

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Research Article

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy

Nahuai Badiola,

Affiliations Instituto de Investigacions Biomediques Sant Pau, Hospital de Sant Pau, Barcelona, Spain, Centro de Investigación Biomédica en Red para enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
Rita Machado de Oliveira,

Affiliation Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal
⨯
Federico Herrera,

Affiliation Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal
⨯
Cristina Guardia-Laguarta,

Affiliations Instituto de Investigacions Biomediques Sant Pau, Hospital de Sant Pau, Barcelona, Spain, Centro de Investigación Biomédica en Red para enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
Susana A. Gonçalves,

Affiliation Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal
⨯
Marta Pera,

Affiliations Instituto de Investigacions Biomediques Sant Pau, Hospital de Sant Pau, Barcelona, Spain, Centro de Investigación Biomédica en Red para enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
Marc Suárez-Calvet,

Affiliations Instituto de Investigacions Biomediques Sant Pau, Hospital de Sant Pau, Barcelona, Spain, Centro de Investigación Biomédica en Red para enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
Jordi Clarimon,

Affiliations Instituto de Investigacions Biomediques Sant Pau, Hospital de Sant Pau, Barcelona, Spain, Centro de Investigación Biomédica en Red para enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
Tiago Fleming Outeiro,

Affiliations Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
⨯
Alberto Lleó

* E-mail: alleo@santpau.es

Affiliations Instituto de Investigacions Biomediques Sant Pau, Hospital de Sant Pau, Barcelona, Spain, Centro de Investigación Biomédica en Red para enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy

Nahuai Badiola,
Rita Machado de Oliveira,
Federico Herrera,
Cristina Guardia-Laguarta,
Susana A. Gonçalves,
Marta Pera,
Marc Suárez-Calvet,
Jordi Clarimon,
Tiago Fleming Outeiro,
Alberto Lleó

Published: October 24, 2011
https://doi.org/10.1371/journal.pone.0026609

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