Pyomelanin Formation in Aspergillus fumigatus Requires HmgX and the Transcriptional Activator HmgR but Is Dispensable for Virulence

Sophia Keller; Juliane Macheleidt; Kirstin Scherlach; Jeannette Schmaler-Ripcke; Ilse D. Jacobsen; Thorsten Heinekamp; Axel A. Brakhage

doi:10.1371/journal.pone.0026604

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Peer-reviewed

Research Article

Pyomelanin Formation in Aspergillus fumigatus Requires HmgX and the Transcriptional Activator HmgR but Is Dispensable for Virulence

Sophia Keller ,

Contributed equally to this work with: Sophia Keller, Juliane Macheleidt

Affiliations Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany, Department of Microbiology and Molecular Biology, Friedrich Schiller University, Jena, Germany
⨯
Juliane Macheleidt ,

Contributed equally to this work with: Sophia Keller, Juliane Macheleidt

Affiliations Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany, Department of Microbiology and Molecular Biology, Friedrich Schiller University, Jena, Germany
⨯
Kirstin Scherlach,

Affiliation Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany
⨯
Jeannette Schmaler-Ripcke,

Affiliation Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany
⨯
Ilse D. Jacobsen,

Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany
⨯
Thorsten Heinekamp ,

* E-mail: axel.brakhage@hki-jena.de (AAB); thorsten.heinekamp@hki-jena.de (TH)

Affiliations Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany, Department of Microbiology and Molecular Biology, Friedrich Schiller University, Jena, Germany
⨯
Axel A. Brakhage

* E-mail: axel.brakhage@hki-jena.de (AAB); thorsten.heinekamp@hki-jena.de (TH)

Affiliations Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany, Department of Microbiology and Molecular Biology, Friedrich Schiller University, Jena, Germany
⨯

Pyomelanin Formation in Aspergillus fumigatus Requires HmgX and the Transcriptional Activator HmgR but Is Dispensable for Virulence

Sophia Keller,
Juliane Macheleidt,
Kirstin Scherlach,
Jeannette Schmaler-Ripcke,
Ilse D. Jacobsen,
Thorsten Heinekamp,
Axel A. Brakhage

Published: October 27, 2011
https://doi.org/10.1371/journal.pone.0026604

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