3-Hydroxy Kynurenine Treatment Controls T. cruzi Replication and the Inflammatory Pathology Preventing the Clinical Symptoms of Chronic Chagas Disease

Carolina P. Knubel; Fernando F. Martínez; Eva V. Acosta Rodríguez; Andrés Altamirano; Héctor W. Rivarola; Cintia Diaz Luján; Ricardo E. Fretes; Laura Cervi; Claudia C. Motrán

doi:10.1371/journal.pone.0026550

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Peer-reviewed

Research Article

3-Hydroxy Kynurenine Treatment Controls T. cruzi Replication and the Inflammatory Pathology Preventing the Clinical Symptoms of Chronic Chagas Disease

Carolina P. Knubel,

Affiliation Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina
⨯
Fernando F. Martínez,

Affiliation Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina
⨯
Eva V. Acosta Rodríguez,

Affiliation Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina
⨯
Andrés Altamirano,

Affiliation Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina
⨯
Héctor W. Rivarola,

Affiliation Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa, Córdoba, Argentina
⨯
Cintia Diaz Luján,

Affiliation Facultad de Medicina, Instituto de Biología Celular, Universidad Nacional de Córdoba, Córdoba, Argentina
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Ricardo E. Fretes,

Affiliation Facultad de Medicina, Instituto de Biología Celular, Universidad Nacional de Córdoba, Córdoba, Argentina
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Laura Cervi,

Affiliation Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina
⨯
Claudia C. Motrán

* E-mail: cmotran@fcq.unc.edu.ar

Affiliation Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina
⨯

3-Hydroxy Kynurenine Treatment Controls T. cruzi Replication and the Inflammatory Pathology Preventing the Clinical Symptoms of Chronic Chagas Disease

Carolina P. Knubel,
Fernando F. Martínez,
Eva V. Acosta Rodríguez,
Andrés Altamirano,
Héctor W. Rivarola,
Cintia Diaz Luján,
Ricardo E. Fretes,
Laura Cervi,
Claudia C. Motrán

Published: October 19, 2011
https://doi.org/10.1371/journal.pone.0026550

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