Is Mitochondrial tRNAphe Variant m.593T>C a Synergistically Pathogenic Mutation in Chinese LHON Families with m.11778G>A?

A-Mei Zhang; Hans-Jürgen Bandelt; Xiaoyun Jia; Wen Zhang; Shiqiang Li; Dandan Yu; Dong Wang; Xin-Ying Zhuang; Qingjiong Zhang; Yong-Gang Yao

doi:10.1371/journal.pone.0026511

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Research Article

Is Mitochondrial tRNA^phe Variant m.593T>C a Synergistically Pathogenic Mutation in Chinese LHON Families with m.11778G>A?

A-Mei Zhang,

Affiliations Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China, Graduate School of the Chinese Academy of Sciences, Beijing, China
⨯
Hans-Jürgen Bandelt,

Affiliation Department of Mathematics, University of Hamburg, Hamburg, Germany
⨯
Xiaoyun Jia,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Wen Zhang,

Affiliations Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China, Graduate School of the Chinese Academy of Sciences, Beijing, China
⨯
Shiqiang Li,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Dandan Yu,

Affiliation Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China
⨯
Dong Wang,

Affiliations Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China, Graduate School of the Chinese Academy of Sciences, Beijing, China
⨯
Xin-Ying Zhuang,

Affiliation Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China
⨯
Qingjiong Zhang ,

* E-mail: qingjiongzhang@yahoo.com (QZ); ygyaozh@gmail.com (YGY)

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Yong-Gang Yao

* E-mail: qingjiongzhang@yahoo.com (QZ); ygyaozh@gmail.com (YGY)

Affiliation Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China
⨯

Is Mitochondrial tRNA^phe Variant m.593T>C a Synergistically Pathogenic Mutation in Chinese LHON Families with m.11778G>A?

A-Mei Zhang,
Hans-Jürgen Bandelt,
Xiaoyun Jia,
Wen Zhang,
Shiqiang Li,
Dandan Yu,
Dong Wang,
Xin-Ying Zhuang,
Qingjiong Zhang,
Yong-Gang Yao

Published: October 19, 2011
https://doi.org/10.1371/journal.pone.0026511

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