Identification of Direct Target Engagement Biomarkers for Kinase-Targeted Therapeutics

• Cloud P. Paweletz ,

  Contributed equally to this work with: Cloud P. Paweletz, Jannik N. Andersen

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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• Jannik N. Andersen ,

  Contributed equally to this work with: Cloud P. Paweletz, Jannik N. Andersen

  Current address: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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• Roy Pollock,

  Current address: Epizyme, Inc., Cambridge, Massachusetts, United States of America

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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• Kumiko Nagashima,

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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• Mansuo L. Hayashi,

  Affiliations Merck & Co., Inc., Boston, Massachusetts, United States of America, Merck & Co., Inc., West Point, Pennsylvania, United States of America

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• Shangshuan U. Yu,

  Current address: CHDI Foundation, Inc., Los Angeles, California, United States of America

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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• Hongbo Guo,

  Current address: University of Toronto, Ontario, Canada

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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• Ekaterina V. Bobkova,

  Current address: Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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• Zangwei Xu,

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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• Alan Northrup,

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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• Peter Blume-Jensen ,

  * E-mail: pblumejensen@metamarkgenetics.com (PBJ); an_chi@merck.com (AC)

  Affiliation Metamark Genetics, Inc, Cambridge, Massachusettes, United States of America

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• Ronald C. Hendrickson,

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• An Chi

  * E-mail: pblumejensen@metamarkgenetics.com (PBJ); an_chi@merck.com (AC)

  Affiliation Merck & Co., Inc., Boston, Massachusetts, United States of America

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