Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells Fate

Michal Mauda-Havakuk; Naomi Litichever; Ellad Chernichovski; Odelia Nakar; Eyal Winkler; Ram Mazkereth; Arie Orenstein; Eran Bar-Meir; Philippe Ravassard; Irit Meivar-Levy; Sarah Ferber

doi:10.1371/journal.pone.0026298

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Open Access

Peer-reviewed

Research Article

Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells Fate

Michal Mauda-Havakuk ,

Contributed equally to this work with: Michal Mauda-Havakuk, Naomi Litichever

Affiliations Sheba Regenerative Medicine, Stem Cells and Tissue Engineering Center, Sheba Medical Center, Tel-Hashomer, Israel, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Naomi Litichever ,

Contributed equally to this work with: Michal Mauda-Havakuk, Naomi Litichever

Affiliations Sheba Regenerative Medicine, Stem Cells and Tissue Engineering Center, Sheba Medical Center, Tel-Hashomer, Israel, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Ellad Chernichovski,

Affiliations Sheba Regenerative Medicine, Stem Cells and Tissue Engineering Center, Sheba Medical Center, Tel-Hashomer, Israel, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Odelia Nakar,

Affiliations Sheba Regenerative Medicine, Stem Cells and Tissue Engineering Center, Sheba Medical Center, Tel-Hashomer, Israel, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Eyal Winkler,

Affiliation Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Tel-Hashomer, Israel
⨯
Ram Mazkereth,

Affiliation Albert Katz Department of Neonatology, Sheba Medical Center, Tel-Hashomer, Israel
⨯
Arie Orenstein,

Affiliation Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Tel-Hashomer, Israel
⨯
Eran Bar-Meir,

Affiliation Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Tel-Hashomer, Israel
⨯
Philippe Ravassard,

Affiliation Biotechnology and Biotherapy group Centre de Recherche Institut du Cerveau et de la Moelle CNRS UMR7225, INSERM UMRS795, Université Pierre et Marie Curie, Paris, France
⨯
Irit Meivar-Levy,

Affiliation Sheba Regenerative Medicine, Stem Cells and Tissue Engineering Center, Sheba Medical Center, Tel-Hashomer, Israel
⨯
Sarah Ferber

* E-mail: sferber@sheba.health.gov.il

Affiliations Sheba Regenerative Medicine, Stem Cells and Tissue Engineering Center, Sheba Medical Center, Tel-Hashomer, Israel, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯

Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells Fate

Michal Mauda-Havakuk,
Naomi Litichever,
Ellad Chernichovski,
Odelia Nakar,
Eyal Winkler,
Ram Mazkereth,
Arie Orenstein,
Eran Bar-Meir,
Philippe Ravassard,
Irit Meivar-Levy

Published: October 18, 2011
https://doi.org/10.1371/journal.pone.0026298

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