A Novel Metagenomic Short-Chain Dehydrogenase/Reductase Attenuates Pseudomonas aeruginosa Biofilm Formation and Virulence on Caenorhabditis elegans

Patrick Bijtenhoorn; Hubert Mayerhofer; Jochen Müller-Dieckmann; Christian Utpatel; Christina Schipper; Claudia Hornung; Matthias Szesny; Stephanie Grond; Andrea Thürmer; Elzbieta Brzuszkiewicz; Rolf Daniel; Katja Dierking; Hinrich Schulenburg; Wolfgang R. Streit

doi:10.1371/journal.pone.0026278

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Peer-reviewed

Research Article

A Novel Metagenomic Short-Chain Dehydrogenase/Reductase Attenuates Pseudomonas aeruginosa Biofilm Formation and Virulence on Caenorhabditis elegans

Patrick Bijtenhoorn,

Affiliation Abteilung für Mikrobiologie und Biotechnologie, Biozentrum Klein Flottbek, Universität Hamburg, Hamburg, Germany
⨯
Hubert Mayerhofer,

Affiliation EMBL Hamburg Outstation, Hamburg, Germany
⨯
Jochen Müller-Dieckmann,

Affiliation EMBL Hamburg Outstation, Hamburg, Germany
⨯
Christian Utpatel,

Affiliation Abteilung für Mikrobiologie und Biotechnologie, Biozentrum Klein Flottbek, Universität Hamburg, Hamburg, Germany
⨯
Christina Schipper,

Affiliation Abteilung für Mikrobiologie und Biotechnologie, Biozentrum Klein Flottbek, Universität Hamburg, Hamburg, Germany
⨯
Claudia Hornung,

Affiliation Abteilung für Mikrobiologie und Biotechnologie, Biozentrum Klein Flottbek, Universität Hamburg, Hamburg, Germany
⨯
Matthias Szesny,

Affiliation Institut für Organische Chemie, Eberhard Karls Universität Tübingen, Tübingen, Germany
⨯
Stephanie Grond,

Affiliation Institut für Organische Chemie, Eberhard Karls Universität Tübingen, Tübingen, Germany
⨯
Andrea Thürmer,

Affiliation Laboratorium für Genomanalyse, Institut für Mikrobiologie und Genetik, Georg-August-Universität Göttingen, Göttingen, Germany
⨯
Elzbieta Brzuszkiewicz,

Affiliation Laboratorium für Genomanalyse, Institut für Mikrobiologie und Genetik, Georg-August-Universität Göttingen, Göttingen, Germany
⨯
Rolf Daniel,

Affiliation Laboratorium für Genomanalyse, Institut für Mikrobiologie und Genetik, Georg-August-Universität Göttingen, Göttingen, Germany
⨯
Katja Dierking,

Affiliation Department of Evolutionary Ecology and Genetics, Christian-Albrechts Universität zu Kiel, Kiel, Germany
⨯
Hinrich Schulenburg,

Affiliation Department of Evolutionary Ecology and Genetics, Christian-Albrechts Universität zu Kiel, Kiel, Germany
⨯
Wolfgang R. Streit

* E-mail: wolfgang.streit@uni-hamburg.de

Affiliation Abteilung für Mikrobiologie und Biotechnologie, Biozentrum Klein Flottbek, Universität Hamburg, Hamburg, Germany
⨯

A Novel Metagenomic Short-Chain Dehydrogenase/Reductase Attenuates Pseudomonas aeruginosa Biofilm Formation and Virulence on Caenorhabditis elegans

Patrick Bijtenhoorn,
Hubert Mayerhofer,
Jochen Müller-Dieckmann,
Christian Utpatel,
Christina Schipper,
Claudia Hornung,
Matthias Szesny,
Stephanie Grond,
Andrea Thürmer,
Elzbieta Brzuszkiewicz

Published: October 26, 2011
https://doi.org/10.1371/journal.pone.0026278

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Pseudomonas aeruginosa
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Bacterial biofilms
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Gene expression
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Caenorhabditis elegans
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Metagenomics
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Transcriptome analysis
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Oxidoreductases
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