Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells

Jiuping Ji; Robert J. Kinders; Yiping Zhang; Larry Rubinstein; Shivaani Kummar; Ralph E. Parchment; Joseph E. Tomaszewski; James H. Doroshow

doi:10.1371/journal.pone.0026152

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Open Access

Peer-reviewed

Research Article

Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells

Jiuping Ji ,

* E-mail: jijiupi@mail.nih.gov

Affiliation National Clinical Target Validation Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Robert J. Kinders,

Affiliation Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Support Directorate, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Yiping Zhang,

Affiliation National Clinical Target Validation Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Larry Rubinstein,

Affiliation Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Shivaani Kummar,

Affiliations Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Ralph E. Parchment,

Affiliation Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Support Directorate, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Joseph E. Tomaszewski,

Affiliation Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
James H. Doroshow

Affiliations Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯

Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells

Jiuping Ji,
Robert J. Kinders,
Yiping Zhang,
Larry Rubinstein,
Shivaani Kummar,
Ralph E. Parchment,
Joseph E. Tomaszewski,
James H. Doroshow

Published: October 10, 2011
https://doi.org/10.1371/journal.pone.0026152

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