Self-Renewing Pten-/-TP53-/- Protospheres Produce Metastatic Adenocarcinoma Cell Lines with Multipotent Progenitor Activity

Wassim Abou-Kheir; Paul G. Hynes; Philip Martin; Juan Juan Yin; Yen-Nien Liu; Victoria Seng; Ross Lake; Joshua Spurrier; Kathleen Kelly

doi:10.1371/journal.pone.0026112

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Open Access

Peer-reviewed

Research Article

Self-Renewing Pten^-/-TP53^-/- Protospheres Produce Metastatic Adenocarcinoma Cell Lines with Multipotent Progenitor Activity

Wassim Abou-Kheir,

Affiliations Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
⨯
Paul G. Hynes,

Affiliation Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Philip Martin,

Current address: Center for Advanced Preclinical Research, SAIC-NCI, Frederick, Maryland, United States of America

Affiliation Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Juan Juan Yin,

Affiliation Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yen-Nien Liu,

Affiliation Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Victoria Seng,

Affiliation Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ross Lake,

Affiliation Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Joshua Spurrier,

Affiliation Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Kathleen Kelly

* E-mail: kellyka@mail.nih.gov

Affiliation Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Self-Renewing Pten^-/-TP53^-/- Protospheres Produce Metastatic Adenocarcinoma Cell Lines with Multipotent Progenitor Activity

Wassim Abou-Kheir,
Paul G. Hynes,
Philip Martin,
Juan Juan Yin,
Yen-Nien Liu,
Victoria Seng,
Ross Lake,
Joshua Spurrier,
Kathleen Kelly

Published: October 11, 2011
https://doi.org/10.1371/journal.pone.0026112

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