Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns

Catalin S. Buhimschi; Vineet Bhandari; Antonette T. Dulay; Unzila A. Nayeri; Sonya S. Abdel-Razeq; Christian M. Pettker; Stephen Thung; Guomao Zhao; Yiping W. Han; Matthew Bizzarro; Irina A. Buhimschi

doi:10.1371/journal.pone.0026111

Loading metrics

Open Access

Peer-reviewed

Research Article

Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns

Catalin S. Buhimschi ,

* E-mail: catalin.buhimschi@yale.edu

Affiliation Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Vineet Bhandari,

Affiliations Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America, Department of Pediatrics, Division of Perinatal Medicine Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Antonette T. Dulay,

Affiliation Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Unzila A. Nayeri,

Affiliation Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Sonya S. Abdel-Razeq,

Affiliation Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Christian M. Pettker,

Affiliation Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Stephen Thung,

Affiliation Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Guomao Zhao,

Affiliation Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Yiping W. Han,

Affiliation Department of Periodontics, Case Western Reserve University, School of Dental Medicine, Cleveland, Ohio, United States of America
⨯
Matthew Bizzarro,

Affiliation Department of Pediatrics, Division of Perinatal Medicine Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Irina A. Buhimschi

Affiliation Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯

Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns

Catalin S. Buhimschi,
Vineet Bhandari,
Antonette T. Dulay,
Unzila A. Nayeri,
Sonya S. Abdel-Razeq,
Christian M. Pettker,
Stephen Thung,
Guomao Zhao,
Yiping W. Han,
Matthew Bizzarro

Published: October 10, 2011
https://doi.org/10.1371/journal.pone.0026111

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Neonates
Is the Subject Area "Neonates" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Biomarkers
Is the Subject Area "Biomarkers" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Neonatal sepsis
Is the Subject Area "Neonatal sepsis" applicable to this article?

Thanks for your feedback.
Proteomics
Is the Subject Area "Proteomics" applicable to this article?

Thanks for your feedback.
Retinopathy of prematurity
Is the Subject Area "Retinopathy of prematurity" applicable to this article?

Thanks for your feedback.