R1507, an Anti-Insulin-Like Growth Factor-1 Receptor (IGF-1R) Antibody, and EWS/FLI-1 siRNA in Ewing's Sarcoma: Convergence at the IGF/IGFR/Akt Axis

Helen J. Huang; Laura S. Angelo; Jordi Rodon; Michael Sun; Klaus-Peter Kuenkele; Henrique A. Parsons; Jonathan C. Trent; Razelle Kurzrock

doi:10.1371/journal.pone.0026060

Loading metrics

Open Access

Peer-reviewed

Research Article

R1507, an Anti-Insulin-Like Growth Factor-1 Receptor (IGF-1R) Antibody, and EWS/FLI-1 siRNA in Ewing's Sarcoma: Convergence at the IGF/IGFR/Akt Axis

Helen J. Huang ,

Contributed equally to this work with: Helen J. Huang, Laura S. Angelo

Affiliation Phase I Program, Department of Investigational Cancer Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Laura S. Angelo ,

Contributed equally to this work with: Helen J. Huang, Laura S. Angelo

Affiliation Phase I Program, Department of Investigational Cancer Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jordi Rodon,

Affiliations Phase I Program, Department of Investigational Cancer Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America, Servei d'Oncologia Medica, Vall d'Hebron Institute of Oncology, Hospital Universitari Vall d'Hebron, Barcelona, Spain
⨯
Michael Sun,

Affiliation Phase I Program, Department of Investigational Cancer Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Klaus-Peter Kuenkele,

Affiliation Roche Diagnostics GmbH, Penzberg, Germany
⨯
Henrique A. Parsons,

Affiliation Phase I Program, Department of Investigational Cancer Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jonathan C. Trent,

Affiliation Division of Cancer Medicine, Department of Sarcoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Razelle Kurzrock

* E-mail: rkurzroc@mdanderson.org

Affiliation Phase I Program, Department of Investigational Cancer Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯

R1507, an Anti-Insulin-Like Growth Factor-1 Receptor (IGF-1R) Antibody, and EWS/FLI-1 siRNA in Ewing's Sarcoma: Convergence at the IGF/IGFR/Akt Axis

Helen J. Huang,
Laura S. Angelo,
Jordi Rodon,
Michael Sun,
Klaus-Peter Kuenkele,
Henrique A. Parsons,
Jonathan C. Trent,
Razelle Kurzrock

Published: October 11, 2011
https://doi.org/10.1371/journal.pone.0026060

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Ewing sarcoma
Is the Subject Area "Ewing sarcoma" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Cell fusion
Is the Subject Area "Cell fusion" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
HEK 293 cells
Is the Subject Area "HEK 293 cells" applicable to this article?

Thanks for your feedback.
Antibody response
Is the Subject Area "Antibody response" applicable to this article?

Thanks for your feedback.