HIV-1gp120 Induces Neuronal Apoptosis through Enhancement of 4-Aminopyridine-Senstive Outward K+ Currents

Open Access

Peer-reviewed

Research Article

HIV-1gp120 Induces Neuronal Apoptosis through Enhancement of 4-Aminopyridine-Senstive Outward K⁺ Currents

Lina Chen,

Affiliations Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Pharmacology, College of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China
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Jianuo Liu,

Affiliation Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
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Changshui Xu,

Affiliation Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
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James Keblesh,

Affiliation Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
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Weijin Zang,

Affiliation Department of Pharmacology, College of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China
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Huangui Xiong

* E-mail: hxiong@unmc.edu

Affiliations Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
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Apoptosis
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Neurons
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Neuronal tuning
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Neuronal death
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Neuronal dendrites
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Potassium channels
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DAPI staining
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Isozymes
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