Proteasomal Degradation of p53 by Human Papillomavirus E6 Oncoprotein Relies on the Structural Integrity of p53 Core Domain

Xavier Bernard; Philip Robinson; Yves Nominé; Murielle Masson; Sebastian Charbonnier; Juan Ramon Ramirez-Ramos; Francois Deryckere; Gilles Travé; Georges Orfanoudakis

doi:10.1371/journal.pone.0025981

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Peer-reviewed

Research Article

Proteasomal Degradation of p53 by Human Papillomavirus E6 Oncoprotein Relies on the Structural Integrity of p53 Core Domain

Xavier Bernard,

Affiliation Oncoprotéines, UMR 7242 CNRS, Ecole Supérieure de Biotechnologie de Strasbourg, Université de Strasbourg, Illkirch, France
⨯
Philip Robinson,

Affiliation Pharmaco-Epidémiologie, CHU de Bordeaux, INSERM CIC 0005, Université de Bordeaux, Bordeaux, France
⨯
Yves Nominé,

Affiliation Oncoprotéines, UMR 7242 CNRS, Ecole Supérieure de Biotechnologie de Strasbourg, Université de Strasbourg, Illkirch, France
⨯
Murielle Masson,

Affiliation Oncoprotéines, UMR 7242 CNRS, Ecole Supérieure de Biotechnologie de Strasbourg, Université de Strasbourg, Illkirch, France
⨯
Sebastian Charbonnier,

Affiliation Oncoprotéines, UMR 7242 CNRS, Ecole Supérieure de Biotechnologie de Strasbourg, Université de Strasbourg, Illkirch, France
⨯
Juan Ramon Ramirez-Ramos,

Affiliation Oncoprotéines, UMR 7242 CNRS, Ecole Supérieure de Biotechnologie de Strasbourg, Université de Strasbourg, Illkirch, France
⨯
Francois Deryckere,

Affiliation Oncoprotéines, UMR 7242 CNRS, Ecole Supérieure de Biotechnologie de Strasbourg, Université de Strasbourg, Illkirch, France
⨯
Gilles Travé ,

* E-mail: gilles.travé@unistra.fr (GT); georges.orfanoudakis@unistra.fr (GO)

Affiliation Oncoprotéines, UMR 7242 CNRS, Ecole Supérieure de Biotechnologie de Strasbourg, Université de Strasbourg, Illkirch, France
⨯
Georges Orfanoudakis

* E-mail: gilles.travé@unistra.fr (GT); georges.orfanoudakis@unistra.fr (GO)

Affiliation Oncoprotéines, UMR 7242 CNRS, Ecole Supérieure de Biotechnologie de Strasbourg, Université de Strasbourg, Illkirch, France
⨯

Proteasomal Degradation of p53 by Human Papillomavirus E6 Oncoprotein Relies on the Structural Integrity of p53 Core Domain

Xavier Bernard,
Philip Robinson,
Yves Nominé,
Murielle Masson,
Sebastian Charbonnier,
Juan Ramon Ramirez-Ramos,
Francois Deryckere,
Gilles Travé,
Georges Orfanoudakis

Published: October 27, 2011
https://doi.org/10.1371/journal.pone.0025981

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Immunoprecipitation
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NMR spectroscopy
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Protein extraction
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