An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding

• Sergei M. Danilov ,

  Contributed equally to this work with: Sergei M. Danilov, Richard D. Minshall, Edward D. Sturrock

  * E-mail: danilov@uic.edu

  Affiliations Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Institute for Personalized Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Kerry Gordon,

  Affiliation Division of Medical Biochemistry, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa

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• Andrew B. Nesterovitch,

  Affiliation Department of Dermatology, Rush University, Chicago, Illinois, United States of America

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• Heinrich Lünsdorf,

  Affiliation Department of Vaccinology and Applied Microbiology, Helmholtz-Center of Infection Research, Braunschweig, Germany

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• Zhenlong Chen,

  Affiliation Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Maricela Castellon,

  Affiliations Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Isolda A. Popova,

  Affiliation Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America

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• Sergey Kalinin,

  Affiliation Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Emma Mendonca,

  Affiliation Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Pavel A. Petukhov,

  Affiliation Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• David E. Schwartz,

  Affiliation Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Richard D. Minshall ,

  Contributed equally to this work with: Sergei M. Danilov, Richard D. Minshall, Edward D. Sturrock

  Affiliations Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Edward D. Sturrock

  Contributed equally to this work with: Sergei M. Danilov, Richard D. Minshall, Edward D. Sturrock

  Affiliation Division of Medical Biochemistry, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa

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