Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients

Xiaobo Yu; Haiyang Xie; Bajin Wei; Min Zhang; Weilin Wang; Jian Wu; Sheng Yan; Shusen Zheng; Lin Zhou

doi:10.1371/journal.pone.0025933

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Open Access

Peer-reviewed

Research Article

Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients

Xiaobo Yu,

Affiliation Key Lab of Combined Multi-Organ Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Ministry of Public Health, Hangzhou, Zhejiang, China
⨯
Haiyang Xie,

Affiliation Key Lab of Combined Multi-Organ Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Ministry of Public Health, Hangzhou, Zhejiang, China
⨯
Bajin Wei,

Affiliation Key Lab of Combined Multi-Organ Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Ministry of Public Health, Hangzhou, Zhejiang, China
⨯
Min Zhang,

Affiliation Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Weilin Wang,

Affiliation Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Jian Wu,

Affiliation Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Sheng Yan,

Affiliation Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Shusen Zheng ,

* E-mail: shusenzheng@zju.edu.cn (SZ); linzhou19@163.com (LZ)

Affiliations Key Lab of Combined Multi-Organ Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Ministry of Public Health, Hangzhou, Zhejiang, China, Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Lin Zhou

* E-mail: shusenzheng@zju.edu.cn (SZ); linzhou19@163.com (LZ)

Affiliation Key Lab of Combined Multi-Organ Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Ministry of Public Health, Hangzhou, Zhejiang, China
⨯

Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients

Xiaobo Yu,
Haiyang Xie,
Bajin Wei,
Min Zhang,
Weilin Wang,
Jian Wu,
Sheng Yan,
Shusen Zheng,
Lin Zhou

Published: November 14, 2011
https://doi.org/10.1371/journal.pone.0025933

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Haplotypes
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Single nucleotide polymorphisms
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Liver transplantation
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Linkage disequilibrium
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Pharmacokinetics
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Homozygosity
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