Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component

Cindy Tamminga; Martha Sedegah; David Regis; Ilin Chuang; Judith E. Epstein; Michele Spring; Jose Mendoza-Silveiras; Shannon McGrath; Santina Maiolatesi; Sharina Reyes; Victoria Steinbeiss; Charlotte Fedders; Kathryn Smith; Brent House; Harini Ganeshan; Jennylynn Lejano; Esteban Abot; Glenna J. Banania; Renato Sayo; Fouzia Farooq; Maria Belmonte; Jittawadee Murphy; Jack Komisar; Jackie Williams; Meng Shi; Donald Brambilla; Nalini Manohar; Nancy O. Richie; Chloe Wood; Keith Limbach; Noelle B. Patterson; Joseph T. Bruder; Denise L. Doolan; C. Richter King; Carter Diggs; Lorraine Soisson; Daniel Carucci; Gail Levine; Sheetij Dutta; Michael R. Hollingdale; Christian F. Ockenhouse; Thomas L. Richie

doi:10.1371/journal.pone.0025868

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Peer-reviewed

Research Article

Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component

Cindy Tamminga ,

* E-mail: cindy.tamminga@med.navy.mil

Affiliation U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
⨯
Martha Sedegah,

Affiliation U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
⨯
David Regis,

Affiliation U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
⨯
Ilin Chuang,

Affiliation U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
⨯
Judith E. Epstein,

Affiliation U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
⨯
Michele Spring,

Affiliations U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Jose Mendoza-Silveiras,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Shannon McGrath,

Affiliations U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Clinical Research Management, Hinckley, Ohio, United States of America
⨯
Santina Maiolatesi,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Sharina Reyes,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Victoria Steinbeiss,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Charlotte Fedders,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Kathryn Smith,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Brent House,

Affiliation U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
⨯
Harini Ganeshan,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Jennylynn Lejano,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Esteban Abot,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Glenna J. Banania,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Renato Sayo,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Fouzia Farooq,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Maria Belmonte,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Jittawadee Murphy,

Affiliation U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Jack Komisar,

Affiliation U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Jackie Williams,

Affiliations U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Clinical Research Management, Hinckley, Ohio, United States of America
⨯
Meng Shi,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Donald Brambilla,

Affiliation RTI Rockville, Rockville, Maryland, United States of America
⨯
Nalini Manohar,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Nancy O. Richie,

Affiliations U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Clinical Research Management, Hinckley, Ohio, United States of America
⨯
Chloe Wood,

Affiliations U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Clinical Research Management, Hinckley, Ohio, United States of America
⨯
Keith Limbach,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Noelle B. Patterson,

Affiliations U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America
⨯
Joseph T. Bruder,

Affiliation GenVec, Inc. Gaithersburg, Maryland, United States of America
⨯
Denise L. Doolan,

Current address: Queensland Institute for Medical Research, Brisbane, Queensland, Australia

Affiliation U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
⨯
C. Richter King,

Affiliation GenVec, Inc. Gaithersburg, Maryland, United States of America
⨯
Carter Diggs,

Affiliation USAID, Washington, D. C., United States of America
⨯
Lorraine Soisson,

Affiliation USAID, Washington, D. C., United States of America
⨯
Daniel Carucci,

Current address: United Nations Foundation, Washington, D. C., United States of America

Affiliation U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
⨯
Gail Levine,

Affiliation Foundation for the National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Sheetij Dutta,

Affiliations U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Clinical Research Management, Hinckley, Ohio, United States of America
⨯
Michael R. Hollingdale,

Affiliation USMMVP, Malaria Department, NMRC, Silver Spring, Maryland, United States of America
⨯
Christian F. Ockenhouse,

Affiliation U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
[ ... ],
Thomas L. Richie

Affiliation U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
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Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component

Cindy Tamminga,
Martha Sedegah,
David Regis,
Ilin Chuang,
Judith E. Epstein,
Michele Spring,
Jose Mendoza-Silveiras,
Shannon McGrath,
Santina Maiolatesi,
Sharina Reyes

Published: October 7, 2011
https://doi.org/10.1371/journal.pone.0025868

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