Dengue Type 4 Live-Attenuated Vaccine Viruses Passaged in Vero Cells Affect Genetic Stability and Dengue-Induced Hemorrhaging in Mice

Open Access

Peer-reviewed

Research Article

Hsiang-Chi Lee,

Affiliation Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
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Yu-Ting Yen,

Affiliation Graduate Institute of Immunology, National Taiwan University, College of Medicine, Taipei, Taiwan
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Wen-Yu Chen,

Affiliation Graduate Institute of Immunology, National Taiwan University, College of Medicine, Taipei, Taiwan
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Betty A. Wu-Hsieh,

Affiliation Graduate Institute of Immunology, National Taiwan University, College of Medicine, Taipei, Taiwan
⨯
Suh-Chin Wu

* E-mail: scwu@mx.nthu.edu.tw

Affiliations Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan
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Vero cells
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Hemorrhage
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Microbial mutation
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Dengue virus
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Mouse models
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Cloning
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Viral vaccines
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Nucleotides
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