HLA-DRB1 May Be Antagonistically Regulated by the Coordinately Evolved Promoter and 3′-UTR under Stabilizing Selection

Benrong Liu; Yonggui Fu; Zhifen Wang; Sisi Zhou; Yu Sun; Yuping Wu; Anlong Xu

doi:10.1371/journal.pone.0025794

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Peer-reviewed

Research Article

HLA-DRB1 May Be Antagonistically Regulated by the Coordinately Evolved Promoter and 3′-UTR under Stabilizing Selection

Benrong Liu,

Affiliation State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutic Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China
⨯
Yonggui Fu,

Affiliation State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutic Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China
⨯
Zhifen Wang,

Affiliation State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutic Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China
⨯
Sisi Zhou,

Affiliation State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutic Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China
⨯
Yu Sun,

Affiliation State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutic Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China
⨯
Yuping Wu,

Affiliation State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutic Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China
⨯
Anlong Xu

* E-mail: lssxal@mail.sysu.edu.cn

Affiliation State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutic Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China
⨯

HLA-DRB1 May Be Antagonistically Regulated by the Coordinately Evolved Promoter and 3′-UTR under Stabilizing Selection

Benrong Liu,
Yonggui Fu,
Zhifen Wang,
Sisi Zhou,
Yu Sun,
Yuping Wu,
Anlong Xu

Published: October 18, 2011
https://doi.org/10.1371/journal.pone.0025794

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Gene expression
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Haplotypes
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Luciferase
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Promoter regions
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Major histocompatibility complex
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Phylogenetic analysis
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T cells
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Natural selection
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