Humanizing π-Class Glutathione S-Transferase Regulation in a Mouse Model Alters Liver Toxicity in Response to Acetaminophen Overdose

• Matthew P. Vaughn ,

  Contributed equally to this work with: Matthew P. Vaughn, Debika Biswal Shinohara

  Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Debika Biswal Shinohara ,

  Contributed equally to this work with: Matthew P. Vaughn, Debika Biswal Shinohara

  Affiliations Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Nicole Castagna,

  Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Jessica L. Hicks,

  Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• George Netto,

  Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Angelo M. De Marzo,

  Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Traci J. Speed,

  Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Zachery R. Reichert,

  Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Bernard Kwabi-Addo,

  Affiliation Howard University Cancer Center, Howard University, Washington, District of Columbia, United States of America

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• Colin J. Henderson,

  Affiliation Cancer Research United Kingdom Molecular Pharmacology Unit, Biomedical Research Institute, Ninewells Hospital and Medical School, Dundee, United Kingdom

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• C. Roland Wolf,

  Affiliation Cancer Research United Kingdom Molecular Pharmacology Unit, Biomedical Research Institute, Ninewells Hospital and Medical School, Dundee, United Kingdom

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• Srinivasan Yegnasubramanian ,

  * E-mail: syegnasu@jhmi.edu (SY); bnelson@jhmi.edu (WN)

  Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• William G. Nelson

  * E-mail: syegnasu@jhmi.edu (SY); bnelson@jhmi.edu (WN)

  Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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