Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

Ana L. Alessandri; Rodger Duffin; Andrew E. Leitch; Christopher D. Lucas; Tara A. Sheldrake; David A. Dorward; Nik Hirani; Vanessa Pinho; Lirlândia Pires de Sousa; Mauro M. Teixeira; John F. Lyons; Christopher Haslett; Adriano G. Rossi

doi:10.1371/journal.pone.0025683

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Peer-reviewed

Research Article

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

Ana L. Alessandri,

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯
Rodger Duffin ,

* E-mail: rodger.duffin@ed.ac.uk

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯
Andrew E. Leitch,

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯
Christopher D. Lucas,

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯
Tara A. Sheldrake,

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯
David A. Dorward,

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯
Nik Hirani,

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯
Vanessa Pinho,

Affiliation Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
⨯
Lirlândia Pires de Sousa,

Affiliation Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
⨯
Mauro M. Teixeira,

Affiliation Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
⨯
John F. Lyons,

Affiliation Astex Therapeutics, Cambridge, England, United Kingdom
⨯
Christopher Haslett,

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯
Adriano G. Rossi

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

Ana L. Alessandri,
Rodger Duffin,
Andrew E. Leitch,
Christopher D. Lucas,
Tara A. Sheldrake,
David A. Dorward,
Nik Hirani,
Vanessa Pinho,
Lirlândia Pires de Sousa,
Mauro M. Teixeira

Published: September 30, 2011
https://doi.org/10.1371/journal.pone.0025683

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Apoptosis
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Eosinophils
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Inflammation
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