Long-Term Sphere Culture Cannot Maintain a High Ratio of Cancer Stem Cells: A Mathematical Model and Experiment

Open Access

Peer-reviewed

Research Article

Tang Peng,

Affiliation Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
⨯
Ma Qinghua,

Affiliation Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
⨯
Tang Zhenning,

Affiliation Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
⨯
Wang Kaifa ,

* E-mail: kaifawang@yahoo.com.cn (WK); jcbd@medmail.com.cn (JJ)

Affiliation Department of Medical Device and Equipment, School of Biomedical Engineering and Medical Imaging, Third Military Medical University, Chongqing, People's Republic of China
⨯
Jiang Jun

* E-mail: kaifawang@yahoo.com.cn (WK); jcbd@medmail.com.cn (JJ)

Affiliation Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
⨯

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Differentiated tumors
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Cancer stem cells
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Breast cancer
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Cell cycle and cell division
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Flow cytometry
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Colorectal cancer
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Mathematical models
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Differential equations
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