PCBP2 Enhances the Antiviral Activity of IFN-α against HCV by Stabilizing the mRNA of STAT1 and STAT2

Zhongshuai Xin; Wei Han; Zhiqiang Zhao; Qing Xia; Bin Yin; Jiangang Yuan; Xiaozhong Peng

doi:10.1371/journal.pone.0025419

Loading metrics

Open Access

Peer-reviewed

Research Article

PCBP2 Enhances the Antiviral Activity of IFN-α against HCV by Stabilizing the mRNA of STAT1 and STAT2

Zhongshuai Xin,

Affiliations National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Division of Biochemical and Gene Engineering Medicines, National Institute for Food and Drug Control, Beijing, China
⨯
Wei Han,

Affiliation National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Zhiqiang Zhao,

Affiliation National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Qing Xia,

Affiliation National Center of Biomedical Analysis, Beijing, China
⨯
Bin Yin,

Affiliation National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jiangang Yuan ,

* E-mail: yuanjiangang@pumc.edu.cn (JY); pengxiaozhong@pumc.edu.cn (XP)

Affiliation National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xiaozhong Peng

* E-mail: yuanjiangang@pumc.edu.cn (JY); pengxiaozhong@pumc.edu.cn (XP)

Affiliation National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯

PCBP2 Enhances the Antiviral Activity of IFN-α against HCV by Stabilizing the mRNA of STAT1 and STAT2

Zhongshuai Xin,
Wei Han,
Zhiqiang Zhao,
Qing Xia,
Bin Yin,
Jiangang Yuan,
Xiaozhong Peng

Published: October 11, 2011
https://doi.org/10.1371/journal.pone.0025419

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hepatitis C virus
Is the Subject Area "Hepatitis C virus" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Antiviral therapy
Is the Subject Area "Antiviral therapy" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Antisense RNA
Is the Subject Area "Antisense RNA" applicable to this article?

Thanks for your feedback.
RNA probes
Is the Subject Area "RNA probes" applicable to this article?

Thanks for your feedback.
Ribonucleoproteins
Is the Subject Area "Ribonucleoproteins" applicable to this article?

Thanks for your feedback.