GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice

Xu Yang; Shinji Kume; Yuki Tanaka; Keiji Isshiki; Shin-ichi Araki; Masami Chin-Kanasaki; Toshiro Sugimoto; Daisuke Koya; Masakazu Haneda; Takeshi Sugaya; Detian Li; Ping Han; Yoshihiko Nishio; Atsunori Kashiwagi; Hiroshi Maegawa; Takashi Uzu

doi:10.1371/journal.pone.0025271

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Peer-reviewed

Research Article

GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice

Xu Yang,

Affiliations Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan, Department of Medicine, Shengjing Hospital of China Medical University, Shenyang, LiaoNing, China
⨯
Shinji Kume,

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
Yuki Tanaka,

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
Keiji Isshiki,

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
Shin-ichi Araki,

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
Masami Chin-Kanasaki,

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
Toshiro Sugimoto,

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
Daisuke Koya,

Affiliation Division of Endocrinology and Metabolism, Kanazawa Medical University, Kahoku-Gun, Ishikawa, Japan
⨯
Masakazu Haneda,

Affiliation Department of Medicine, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
⨯
Takeshi Sugaya,

Affiliation Nephrology and Hypertension, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
⨯
Detian Li,

Affiliation Department of Medicine, Shengjing Hospital of China Medical University, Shenyang, LiaoNing, China
⨯
Ping Han,

Affiliation Department of Medicine, Shengjing Hospital of China Medical University, Shenyang, LiaoNing, China
⨯
Yoshihiko Nishio,

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
Atsunori Kashiwagi,

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
Hiroshi Maegawa,

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
[ ... ],
Takashi Uzu

* E-mail: takuzu@belle.shiga-med.ac.jp

Affiliation Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
⨯
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GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice

Xu Yang,
Shinji Kume,
Yuki Tanaka,
Keiji Isshiki,
Shin-ichi Araki,
Masami Chin-Kanasaki,
Toshiro Sugimoto,
Daisuke Koya,
Masakazu Haneda,
Takeshi Sugaya

Published: September 22, 2011
https://doi.org/10.1371/journal.pone.0025271

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