Hypertonic Stress Induces VEGF Production in Human Colon Cancer Cell Line Caco-2: Inhibitory Role of Autocrine PGE2

Open Access

Peer-reviewed

Research Article

Hypertonic Stress Induces VEGF Production in Human Colon Cancer Cell Line Caco-2: Inhibitory Role of Autocrine PGE₂

Luciana B. Gentile,

Affiliations Divisão de Biologia Celular, Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, Rio de Janeiro, Brasil, Programa de Pós-Graduação em Ciências Morfológicas, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil
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Bruno Piva,

Affiliation Programa de Imunobiologia, Instituto de Biofísica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil
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Bruno L. Diaz

* E-mail: bldiaz@biof.ufrj.br

Affiliation Programa de Imunobiologia, Instituto de Biofísica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil
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Hypertonic
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Caco-2 cells
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Colorectal cancer
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VEGF signaling
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COX-2 inhibitors
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Gastrointestinal cancers
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MAPK signaling cascades
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Angiogenesis
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