Anticancer Effects of 15d-Prostaglandin-J2 in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC

Open Access

Peer-reviewed

Research Article

Anticancer Effects of 15d-Prostaglandin-J₂ in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC

Edwin de Jong ,

Contributed equally to this work with: Edwin de Jong, Peter Winkel

Affiliation Department of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands
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Peter Winkel ,

Contributed equally to this work with: Edwin de Jong, Peter Winkel

Affiliation Department of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands
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Klaas Poelstra,

Affiliations Department of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands, BiOrion Technologies BV, MediTech Center UMCG, L.J. Zielstraweg 1, Groningen, The Netherlands
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Jai Prakash

* E-mail: jai.prakash@ki.se

Current address: Department of Oncology-Pathology, Cancer Centre Karolinska, Karolinska Institutet, Stockholm, Sweden

Affiliations Department of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands, BiOrion Technologies BV, MediTech Center UMCG, L.J. Zielstraweg 1, Groningen, The Netherlands
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Transcription factors
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Gene expression
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Apoptosis
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Ovarian cancer
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Enzyme assays
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Wound healing
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Cell migration
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Enzyme inhibitors
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