Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents

Open Access

Peer-reviewed

Research Article

Malgorzata N. Drwal,

Affiliation Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia
⨯
Keli Agama,

Affiliation Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Laurence P. G. Wakelin,

Affiliation Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia
⨯
Yves Pommier,

Affiliation Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Renate Griffith

* E-mail: r.griffith@unsw.edu.au

Affiliation Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia
⨯

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DNA cleavage
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Crystal structure
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Drug interactions
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Hydrogen bonding
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Drug screening
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Protein interactions
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Toxins
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DNA-binding proteins
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