The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer

Jatin Roper; Michael P. Richardson; Wei Vivian Wang; Larissa Georgeon Richard; Wei Chen; Erin M. Coffee; Mark J. Sinnamon; Lydia Lee; Peng-Chieh Chen; Roderick T. Bronson; Eric S. Martin; Kenneth E. Hung

doi:10.1371/journal.pone.0025132

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Open Access

Peer-reviewed

Research Article

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer

Jatin Roper ,

Contributed equally to this work with: Jatin Roper, Michael P. Richardson

Affiliation Division of Gastroenterology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
⨯
Michael P. Richardson ,

Contributed equally to this work with: Jatin Roper, Michael P. Richardson

Affiliation Division of Gastroenterology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
⨯
Wei Vivian Wang,

Affiliation Division of Gastroenterology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
⨯
Larissa Georgeon Richard,

Affiliation Department of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Wei Chen,

Affiliation Division of Gastroenterology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
⨯
Erin M. Coffee,

Affiliation Division of Gastroenterology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
⨯
Mark J. Sinnamon,

Affiliation Division of Gastroenterology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
⨯
Lydia Lee,

Affiliation Division of Gastroenterology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
⨯
Peng-Chieh Chen,

Affiliation Department of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Roderick T. Bronson,

Affiliation Dana Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Eric S. Martin,

Affiliation Dana Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kenneth E. Hung

* E-mail: khung@tuftsmedicalcenter.org

Affiliation Division of Gastroenterology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
⨯

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer

Jatin Roper,
Michael P. Richardson,
Wei Vivian Wang,
Larissa Georgeon Richard,
Wei Chen,
Erin M. Coffee,
Mark J. Sinnamon,
Lydia Lee,
Peng-Chieh Chen,
Roderick T. Bronson

Published: September 26, 2011
https://doi.org/10.1371/journal.pone.0025132

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