Homozygosity Mapping on Homozygosity Haplotype Analysis to Detect Recessive Disease-Causing Genes from a Small Number of Unrelated, Outbred Patients

Koichi Hagiwara; Hiroyuki Morino; Jun Shiihara; Tomoaki Tanaka; Hitoshi Miyazawa; Tomoko Suzuki; Masakazu Kohda; Yasushi Okazaki; Kuniaki Seyama; Hideshi Kawakami

doi:10.1371/journal.pone.0025059

Loading metrics

Open Access

Peer-reviewed

Research Article

Homozygosity Mapping on Homozygosity Haplotype Analysis to Detect Recessive Disease-Causing Genes from a Small Number of Unrelated, Outbred Patients

Koichi Hagiwara ,

* E-mail: hagiwark@saitama-med.ac.jp

Affiliation Department of Respiratory Medicine, Saitama Medical University, Moroyama, Saitama, Japan
⨯
Hiroyuki Morino,

Affiliation Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Hiroshima, Japan
⨯
Jun Shiihara,

Affiliation Department of Respiratory Medicine, Saitama Medical University, Moroyama, Saitama, Japan
⨯
Tomoaki Tanaka,

Affiliation Department of Respiratory Medicine, Saitama Medical University, Moroyama, Saitama, Japan
⨯
Hitoshi Miyazawa,

Affiliation Department of Respiratory Medicine, Saitama Medical University, Moroyama, Saitama, Japan
⨯
Tomoko Suzuki,

Affiliation Department of Respiratory Medicine, Saitama Medical University, Moroyama, Saitama, Japan
⨯
Masakazu Kohda,

Affiliations Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, Japan, Division of Translational Research, Research Center for Genomic Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, Japan
⨯
Yasushi Okazaki,

Affiliations Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, Japan, Division of Translational Research, Research Center for Genomic Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, Japan
⨯
Kuniaki Seyama,

Affiliation Department of Respiratory Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan
⨯
Hideshi Kawakami

Affiliation Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Hiroshima, Japan
⨯

Homozygosity Mapping on Homozygosity Haplotype Analysis to Detect Recessive Disease-Causing Genes from a Small Number of Unrelated, Outbred Patients

Koichi Hagiwara,
Hiroyuki Morino,
Jun Shiihara,
Tomoaki Tanaka,
Hitoshi Miyazawa,
Tomoko Suzuki,
Masakazu Kohda,
Yasushi Okazaki,
Kuniaki Seyama,
Hideshi Kawakami

Published: September 20, 2011
https://doi.org/10.1371/journal.pone.0025059

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Single nucleotide polymorphisms
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article?

Thanks for your feedback.
Genotyping
Is the Subject Area "Genotyping" applicable to this article?

Thanks for your feedback.
Homozygosity
Is the Subject Area "Homozygosity" applicable to this article?

Thanks for your feedback.
Computer applications
Is the Subject Area "Computer applications" applicable to this article?

Thanks for your feedback.
Haplotypes
Is the Subject Area "Haplotypes" applicable to this article?

Thanks for your feedback.
Genetic loci
Is the Subject Area "Genetic loci" applicable to this article?

Thanks for your feedback.
Homozygosity mapping
Is the Subject Area "Homozygosity mapping" applicable to this article?

Thanks for your feedback.
Genetics of disease
Is the Subject Area "Genetics of disease" applicable to this article?

Thanks for your feedback.