Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

Svetlana Pidasheva; Sara Trifari; Anne Phillips; Jason A. Hackney; Yan Ma; Ashley Smith; Sue J. Sohn; Hergen Spits; Randall D. Little; Timothy W. Behrens; Lee Honigberg; Nico Ghilardi; Hilary F. Clark

doi:10.1371/journal.pone.0025038

Loading metrics

Open Access

Peer-reviewed

Research Article

Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

Svetlana Pidasheva ,

* E-mail: svetlana.pidasheva@gmail.com (SP) (SP); clark.hilary@gene.com (HFC) (HC)

Affiliations Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, California, United States of America, Department of Immunology, Genentech Inc, South San Francisco, California, United States of America
⨯
Sara Trifari,

Current address: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

Affiliation Department of Immunology, Genentech Inc, South San Francisco, California, United States of America
⨯
Anne Phillips,

Current address: Gastrointestinal Unit, University of Edinburgh, Edinburgh, United Kingdom

Affiliation Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, California, United States of America
⨯
Jason A. Hackney,

Affiliation Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, California, United States of America
⨯
Yan Ma,

Affiliation Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, California, United States of America
⨯
Ashley Smith,

Affiliation ITGR Early Development, Genentech Inc, South San Francisco, California, United States of America
⨯
Sue J. Sohn,

Affiliation Department of Immunology, Genentech Inc, South San Francisco, California, United States of America
⨯
Hergen Spits,

Current address: Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Affiliation Department of Immunology, Genentech Inc, South San Francisco, California, United States of America
⨯
Randall D. Little,

Affiliation Genizon BioSciences, Inc., St. Laurent, Quebec, Canada
⨯
Timothy W. Behrens,

Affiliation ITGR Biomarker Discovery Group, Genentech Inc, South San Francisco, California, United States of America
⨯
Lee Honigberg,

Affiliation ITGR Early Development, Genentech Inc, South San Francisco, California, United States of America
⨯
Nico Ghilardi,

Affiliations Department of Immunology, Genentech Inc, South San Francisco, California, United States of America, Department of Molecular Biology, Genentech Inc, South San Francisco, California, United States of America
⨯
Hilary F. Clark

* E-mail: svetlana.pidasheva@gmail.com (SP) (SP); clark.hilary@gene.com (HFC) (HC)

Affiliations Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, California, United States of America, Department of Immunology, Genentech Inc, South San Francisco, California, United States of America
⨯

Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

Svetlana Pidasheva,
Sara Trifari,
Anne Phillips,
Jason A. Hackney,
Yan Ma,
Ashley Smith,
Sue J. Sohn,
Hergen Spits,
Randall D. Little,
Timothy W. Behrens

Published: October 12, 2011
https://doi.org/10.1371/journal.pone.0025038

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Inflammatory bowel disease
Is the Subject Area "Inflammatory bowel disease" applicable to this article?

Thanks for your feedback.