Identification of a Negative Allosteric Site on Human α4β2 and α3β4 Neuronal Nicotinic Acetylcholine Receptors

Open Access

Peer-reviewed

Research Article

Ryan E. Pavlovicz,

Affiliation Biophysics Program, Ohio State University, Columbus, Ohio, United States of America
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Brandon J. Henderson,

Affiliation Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus, Ohio, United States of America
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Andrew B. Bonnell,

Affiliation Department of Neuroscience, Ohio State University, Columbus, Ohio, United States of America
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R. Thomas Boyd,

Affiliation Department of Neuroscience, Ohio State University, Columbus, Ohio, United States of America
⨯
Dennis B. McKay,

Affiliation Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus, Ohio, United States of America
⨯
Chenglong Li

* E-mail: li.728@osu.edu

Affiliations Biophysics Program, Ohio State University, Columbus, Ohio, United States of America, Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio, United States of America
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Nicotinic acetylcholine receptors
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Free energy
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Crystal structure
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Acetylcholine
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Hydrogen bonding
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Molecular dynamics
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Simulation and modeling
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Nicotine
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