The Haploinsufficient Hematopoietic Microenvironment Is Critical to the Pathological Fracture Repair in Murine Models of Neurofibromatosis Type 1

Xiaohua Wu; Shi Chen; Yongzheng He; Steven D. Rhodes; Khalid S. Mohammad; Xiaohong Li; Xianlin Yang; Li Jiang; Grzegorz Nalepa; Paige Snider; Alexander G. Robling; D. Wade Clapp; Simon J. Conway; Theresa A. Guise; Feng-Chun Yang

doi:10.1371/journal.pone.0024917

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Peer-reviewed

Research Article

The Haploinsufficient Hematopoietic Microenvironment Is Critical to the Pathological Fracture Repair in Murine Models of Neurofibromatosis Type 1

Xiaohua Wu,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Shi Chen,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Yongzheng He,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Steven D. Rhodes,

Affiliations Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Khalid S. Mohammad,

Affiliation Endocrinology and Metabolism, Department of Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Xiaohong Li,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Xianlin Yang,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Li Jiang,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Grzegorz Nalepa,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Paige Snider,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Alexander G. Robling,

Affiliation Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
D. Wade Clapp,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Simon J. Conway,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Theresa A. Guise,

Affiliation Endocrinology and Metabolism, Department of Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Feng-Chun Yang

* E-mail: fyang@iupui.edu

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯

The Haploinsufficient Hematopoietic Microenvironment Is Critical to the Pathological Fracture Repair in Murine Models of Neurofibromatosis Type 1

Xiaohua Wu,
Shi Chen,
Yongzheng He,
Steven D. Rhodes,
Khalid S. Mohammad,
Xiaohong Li,
Xianlin Yang,
Li Jiang,
Grzegorz Nalepa,
Paige Snider

Published: September 29, 2011
https://doi.org/10.1371/journal.pone.0024917

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