The Molecular Assembly of Amyloid Aβ Controls Its Neurotoxicity and Binding to Cellular Proteins

Claudia Manzoni; Laura Colombo; Paolo Bigini; Valentina Diana; Alfredo Cagnotto; Massimo Messa; Monica Lupi; Valentina Bonetto; Mauro Pignataro; Cristina Airoldi; Erika Sironi; Alun Williams; Mario Salmona

doi:10.1371/journal.pone.0024909

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Open Access

Peer-reviewed

Research Article

The Molecular Assembly of Amyloid Aβ Controls Its Neurotoxicity and Binding to Cellular Proteins

Claudia Manzoni,

Current address: Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
⨯
Laura Colombo,

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
⨯
Paolo Bigini,

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
⨯
Valentina Diana,

Current address: Istituto Auxologico Italiano, Milan, Italy

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
⨯
Alfredo Cagnotto,

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
⨯
Massimo Messa,

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
⨯
Monica Lupi,

Affiliation Department of Oncology, Mario Negri Institute for Pharmacological Research, Milan, Italy
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Valentina Bonetto,

Affiliations Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy, Dulbecco Telethon Institute, Milan, Italy
⨯
Mauro Pignataro,

Affiliations Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy, Dulbecco Telethon Institute, Milan, Italy
⨯
Cristina Airoldi,

Affiliation Department. of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy
⨯
Erika Sironi,

Affiliation Department. of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy
⨯
Alun Williams,

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
⨯
Mario Salmona

* E-mail: mario.salmona@marionegri.it

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
⨯

The Molecular Assembly of Amyloid Aβ Controls Its Neurotoxicity and Binding to Cellular Proteins

Claudia Manzoni,
Laura Colombo,
Paolo Bigini,
Valentina Diana,
Alfredo Cagnotto,
Massimo Messa,
Monica Lupi,
Valentina Bonetto,
Mauro Pignataro,
Cristina Airoldi

Published: September 23, 2011
https://doi.org/10.1371/journal.pone.0024909

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13 Apr 2014
18:05 GMT
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Intriguing, but... Posted by thomas.esparza on 13 Apr 2014 at 18:05 GMT

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Membrane proteins
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Oligomers
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Toxicity
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Amyloid proteins
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