Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells

Paul Kay; George Schlossmacher; Laura Matthews; Paula Sommer; Dave Singh; Anne White; David Ray

doi:10.1371/journal.pone.0024839

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Peer-reviewed

Research Article

Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells

Paul Kay ,

Contributed equally to this work with: Paul Kay, George Schlossmacher

Affiliation Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
⨯
George Schlossmacher ,

Contributed equally to this work with: Paul Kay, George Schlossmacher

Affiliation Faculty of Life Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
⨯
Laura Matthews,

Affiliation Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
⨯
Paula Sommer,

Affiliations Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom, School of Biological Sciences, University of KwaZulu-Natal, Durban, South Africa
⨯
Dave Singh,

Affiliation Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
⨯
Anne White ,

* E-mail: david.w.ray@manchester.ac.uk (DR); awhite@manchester.ac.uk (AW)

Affiliations Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom, Faculty of Life Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
⨯
David Ray

* E-mail: david.w.ray@manchester.ac.uk (DR); awhite@manchester.ac.uk (AW)

Affiliation Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
⨯

Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells

Paul Kay,
George Schlossmacher,
Laura Matthews,
Paula Sommer,
Dave Singh,
Anne White,
David Ray

Published: October 3, 2011
https://doi.org/10.1371/journal.pone.0024839

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DNA methylation
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Small cell lung cancer
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Apoptosis
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Protein expression
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Tumor suppressor genes
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Gene expression
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HEK 293 cells
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Lung and intrathoracic tumors
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