Co-Crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion

Timo Heikkila; Edward Wheatley; Diane Crighton; Ewald Schroder; Alexandra Boakes; Sarah J. Kaye; Mokdad Mezna; Leon Pang; Mathew Rushbrooke; Andrew Turnbull; Michael F. Olson

doi:10.1371/journal.pone.0024825

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Open Access

Peer-reviewed

Research Article

Co-Crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion

Timo Heikkila,

Affiliation Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, United Kingdom
⨯
Edward Wheatley,

Affiliation Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, United Kingdom
⨯
Diane Crighton,

Affiliation Beatson Institute for Cancer Research, Glasgow, United Kingdom
⨯
Ewald Schroder,

Affiliation Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, United Kingdom
⨯
Alexandra Boakes,

Affiliation Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, United Kingdom
⨯
Sarah J. Kaye,

Affiliation Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, United Kingdom
⨯
Mokdad Mezna,

Affiliation Beatson Institute for Cancer Research, Glasgow, United Kingdom
⨯
Leon Pang,

Affiliation Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, United Kingdom
⨯
Mathew Rushbrooke,

Affiliation Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, United Kingdom
⨯
Andrew Turnbull,

Affiliation Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, United Kingdom
⨯
Michael F. Olson

* E-mail: m.olson@beatson.gla.ac.uk

Affiliation Beatson Institute for Cancer Research, Glasgow, United Kingdom
⨯

Co-Crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion

Timo Heikkila,
Edward Wheatley,
Diane Crighton,
Ewald Schroder,
Alexandra Boakes,
Sarah J. Kaye,
Mokdad Mezna,
Leon Pang,
Mathew Rushbrooke,
Andrew Turnbull

Published: September 20, 2011
https://doi.org/10.1371/journal.pone.0024825

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Small interfering RNA
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Hydrogen bonding
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Crystal structure
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Dimerization
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Cancers and neoplasms
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Crystallization
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Kinase inhibitors
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