Gefitinib Induces Epidermal Growth Factor Receptor Dimers Which Alters the Interaction Characteristics with 125I-EGF

Open Access

Peer-reviewed

Research Article

Gefitinib Induces Epidermal Growth Factor Receptor Dimers Which Alters the Interaction Characteristics with ¹²⁵I-EGF

Hanna Björkelund ,

* E-mail: hanna@ridgeviewinstruments.com

Affiliations Biomedical Radiation Sciences, Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden, Ridgeview Instruments AB, Uppsala, Sweden
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Lars Gedda,

Affiliation Biomedical Radiation Sciences, Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden
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Pavel Barta,

Affiliation Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Prague, Czech Republic
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Magnus Malmqvist,

Affiliations Biomedical Radiation Sciences, Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden, Ridgeview Instruments AB, Uppsala, Sweden, Bioventia AB, Uppsala, Sweden
⨯
Karl Andersson

Affiliations Biomedical Radiation Sciences, Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden, Ridgeview Instruments AB, Uppsala, Sweden
⨯

Dimerization
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Dimers
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Cell binding
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Cross-linking
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Monomers
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Chemical dissociation
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Tyrosine kinase inhibitors
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Binding analysis
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