Bound Water at Protein-Protein Interfaces: Partners, Roles and Hydrophobic Bubbles as a Conserved Motif

• Mostafa H. Ahmed,

  Affiliations Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Francesca Spyrakis,

  Affiliations Department of General and Inorganic Chemistry, University of Parma, Parma, Italy, Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy, Institute of Biostructures and Biosystems, Rome, Italy

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• Pietro Cozzini,

  Affiliations Department of General and Inorganic Chemistry, University of Parma, Parma, Italy, Institute of Biostructures and Biosystems, Rome, Italy

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• Parijat K. Tripathi,

  Affiliation Department of General and Inorganic Chemistry, University of Parma, Parma, Italy

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• Andrea Mozzarelli,

  Affiliations Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy, Institute of Biostructures and Biosystems, Rome, Italy

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• J. Neel Scarsdale,

  Affiliations Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Martin A. Safo,

  Affiliations Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Glen E. Kellogg

  * E-mail: glen.kellogg@vcu.edu

  Affiliations Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America, Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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