Timing Is Critical for an Effective Anti-Metastatic Immunotherapy: The Decisive Role of IFNγ/STAT1-Mediated Activation of Autophagy

Jun Yan; Zi-Yan Wang; Hong-Zhen Yang; Han-Zhi Liu; Su Mi; Xiao-Xi Lv; Xiao-Ming Fu; Hui-Min Yan; Xiao-Wei Zhang; Qi-Min Zhan; Zhuo-Wei Hu

doi:10.1371/journal.pone.0024705

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Open Access

Peer-reviewed

Research Article

Timing Is Critical for an Effective Anti-Metastatic Immunotherapy: The Decisive Role of IFNγ/STAT1-Mediated Activation of Autophagy

Jun Yan,

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Zi-Yan Wang,

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Hong-Zhen Yang,

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Han-Zhi Liu,

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Su Mi,

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xiao-Xi Lv,

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xiao-Ming Fu,

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Hui-Min Yan,

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xiao-Wei Zhang,

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Qi-Min Zhan,

Affiliation State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Zhuo-Wei Hu

* E-mail: huzhuowei@imm.ac.cn

Affiliation Molecular Immunology and Pharmacology Laboratory, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯

Timing Is Critical for an Effective Anti-Metastatic Immunotherapy: The Decisive Role of IFNγ/STAT1-Mediated Activation of Autophagy

Jun Yan,
Zi-Yan Wang,
Hong-Zhen Yang,
Han-Zhi Liu,
Su Mi,
Xiao-Xi Lv,
Xiao-Ming Fu,
Hui-Min Yan,
Xiao-Wei Zhang,
Qi-Min Zhan

Published: September 13, 2011
https://doi.org/10.1371/journal.pone.0024705

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