APOE Genotype-Function Relationship: Evidence of −491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk

Hua Geng; Peggy P. Y. Law; Maggie C. Y. Ng; Ting Li; Li-Yun Liang; Tian-Fang Ge; Kam-Bo Wong; Chun Liang; Ronald C. Ma; Wing-Yee So; Juliana C. N. Chan; Yuan-Yuan Ho

doi:10.1371/journal.pone.0024669

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Open Access

Peer-reviewed

Research Article

APOE Genotype-Function Relationship: Evidence of −491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk

Hua Geng,

Current address: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

Affiliation Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Peggy P. Y. Law,

Affiliation Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Maggie C. Y. Ng,

Affiliation Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Ting Li,

Affiliation Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Li-Yun Liang,

Affiliation Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Tian-Fang Ge,

Affiliation Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Kam-Bo Wong,

Affiliation Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Chun Liang,

Affiliation Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
⨯
Ronald C. Ma,

Affiliation Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Wing-Yee So,

Affiliation Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Juliana C. N. Chan,

Affiliation Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
⨯
Yuan-Yuan Ho

* E-mail: yyh2@columbia.edu

Affiliations Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China, Genetics of Complex Disorder Program, Departments of Biostatistics and Psychiatry, Columbia University, New York, New York, United States of America
⨯

APOE Genotype-Function Relationship: Evidence of −491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk

Hua Geng,
Peggy P. Y. Law,
Maggie C. Y. Ng,
Ting Li,
Li-Yun Liang,
Tian-Fang Ge,
Kam-Bo Wong,
Chun Liang,
Ronald C. Ma,
Wing-Yee So

Published: October 18, 2011
https://doi.org/10.1371/journal.pone.0024669

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Type 2 diabetes
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Apolipoprotein genes
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Transcription factors
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Transfection
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Variant genotypes
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Single nucleotide polymorphisms
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