HCV Causes Chronic Endoplasmic Reticulum Stress Leading to Adaptation and Interference with the Unfolded Protein Response

• Emmanuelle Merquiol,

  Affiliation Liver Unit, Division of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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• Dotan Uzi,

  Affiliation Liver Unit, Division of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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• Tobias Mueller,

  Affiliation Medizinische Klinik M. S. Hepatologie und Gastroenterologie, Charité -Universitätsmedizin Berlin, CVK, Berlin, Germany

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• Daniel Goldenberg,

  Affiliation Goldyne Savad Institute of Gene Therapy, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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• Yaakov Nahmias,

  Affiliation Center for Bioengineering, Rachel and Selim Benin School of Computer Science and Engineering, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

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• Ramnik J. Xavier,

  Affiliation Gastroenterology Unit, Center for the Study of Inflammatory Bowel Disease, and Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Boaz Tirosh ,

  Contributed equally to this work with: Boaz Tirosh, Oren Shibolet

  Affiliation Institute for Drug Research, School of Pharmacology, Faculty of Medicine, Jerusalem, Israel

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• Oren Shibolet

  Contributed equally to this work with: Boaz Tirosh, Oren Shibolet

  * E-mail: orensh@tasmc.health.gov.il

  Affiliation Liver Unit, Department of Gastroenterology and Liver Disease, Tel-Aviv Sourasky Medical-Center, Tel-Aviv, Israel

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