Copy Number and Loss of Heterozygosity Detected by SNP Array of Formalin-Fixed Tissues Using Whole-Genome Amplification

Angela Stokes; Ignat Drozdov; Eliete Guerra; Christos A. Ouzounis; Saman Warnakulasuriya; Michael J. Gleeson; Mark McGurk; Mahvash Tavassoli; Edward W. Odell

doi:10.1371/journal.pone.0024503

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Open Access

Peer-reviewed

Research Article

Copy Number and Loss of Heterozygosity Detected by SNP Array of Formalin-Fixed Tissues Using Whole-Genome Amplification

Angela Stokes ,

* E-mail: angela.stokes@kcl.ac.uk

Affiliation Department of Oral Pathology, King's College London Dental Institute, London, United Kingdom
⨯
Ignat Drozdov,

Affiliations Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, London, United Kingdom, Department of Informatics, Centre for Bioinformatics, School of Natural and Mathematical Sciences, King's College London, London, United Kingdom
⨯
Eliete Guerra,

Affiliations Department of Oral Pathology, King's College London Dental Institute, London, United Kingdom, Oral Pathology, Department of Dentistry, Faculty of Health Science, University of Brasilia, Brasilia, Brazil
⨯
Christos A. Ouzounis,

Current address: Institute of Agrobiotechnology, Centre for Research and Technology Hellas, Thessaloniki, Greece

Affiliation Department of Informatics, Centre for Bioinformatics, School of Natural and Mathematical Sciences, King's College London, London, United Kingdom
⨯
Saman Warnakulasuriya,

Affiliation Department of Oral Medicine, King's College London Dental Institute, London, United Kingdom
⨯
Michael J. Gleeson,

Affiliation Department of Otolaryngology, Guy's Hospital, London, United Kingdom
⨯
Mark McGurk,

Affiliation Department of Oral and Maxillofacial Surgery, King's College London Dental Institute, London, United Kingdom
⨯
Mahvash Tavassoli,

Affiliation Department of Oral Pathology, King's College London Dental Institute, London, United Kingdom
⨯
Edward W. Odell

Affiliation Department of Oral Pathology, King's College London Dental Institute, London, United Kingdom
⨯

Copy Number and Loss of Heterozygosity Detected by SNP Array of Formalin-Fixed Tissues Using Whole-Genome Amplification

Angela Stokes,
Ignat Drozdov,
Eliete Guerra,
Christos A. Ouzounis,
Saman Warnakulasuriya,
Michael J. Gleeson,
Mark McGurk,
Mahvash Tavassoli,
Edward W. Odell

Published: September 26, 2011
https://doi.org/10.1371/journal.pone.0024503

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Single nucleotide polymorphisms
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Whole genome amplification
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Polymerase chain reaction
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Genomics
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Genotyping
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Heterozygosity
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Protein interaction networks
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Signal amplification
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