Cellular Stress Induced Alterations in MicroRNA let-7a and let-7b Expression Are Dependent on p53

Anthony D. Saleh; Jason E. Savage; Liu Cao; Benjamin P. Soule; David Ly; William DeGraff; Curtis C. Harris; James B. Mitchell; Nicole L. Simone

doi:10.1371/journal.pone.0024429

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Open Access

Peer-reviewed

Research Article

Cellular Stress Induced Alterations in MicroRNA let-7a and let-7b Expression Are Dependent on p53

Anthony D. Saleh,

Affiliation Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jason E. Savage,

Affiliation Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Liu Cao,

Affiliation Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Benjamin P. Soule,

Affiliation Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
David Ly,

Affiliation Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
William DeGraff,

Affiliation Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Curtis C. Harris,

Affiliation Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
James B. Mitchell,

Affiliation Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Nicole L. Simone

* E-mail: simonen@mail.nih.gov

Affiliation Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Cellular Stress Induced Alterations in MicroRNA let-7a and let-7b Expression Are Dependent on p53

Anthony D. Saleh,
Jason E. Savage,
Liu Cao,
Benjamin P. Soule,
David Ly,
William DeGraff,
Curtis C. Harris,
James B. Mitchell,
Nicole L. Simone

Published: October 11, 2011
https://doi.org/10.1371/journal.pone.0024429

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MicroRNAs
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Transfection
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Luciferase
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Fibroblasts
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Lung and intrathoracic tumors
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Gene expression
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Polymerase chain reaction
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Cellular stress responses
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