Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome

Stine A. Danielsen; Lina Cekaite; Trude H. Ågesen; Anita Sveen; Arild Nesbakken; Espen Thiis-Evensen; Rolf I. Skotheim; Guro E. Lind; Ragnhild A. Lothe

doi:10.1371/journal.pone.0024419

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Open Access

Peer-reviewed

Research Article

Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome

Stine A. Danielsen,

Affiliations Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
⨯
Lina Cekaite,

Affiliations Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
⨯
Trude H. Ågesen,

Affiliations Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
⨯
Anita Sveen,

Affiliations Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
⨯
Arild Nesbakken,

Affiliations Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Gastrointestinal Surgery, Oslo University Hospital, Oslo, Norway
⨯
Espen Thiis-Evensen ,

¶Author also represents the INFAC study group.

Affiliation Department of Organ Transplantation, Gastroenterology, and Nephrology, Oslo University Hospital, Oslo, Norway
⨯
Rolf I. Skotheim,

Affiliations Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
⨯
Guro E. Lind,

Affiliations Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
⨯
Ragnhild A. Lothe

* E-mail: Ragnhild.A.Lothe@rr-research.no

Affiliations Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
⨯

Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome

Stine A. Danielsen,
Lina Cekaite,
Trude H. Ågesen,
Anita Sveen,
Arild Nesbakken,
Espen Thiis-Evensen,
Rolf I. Skotheim,
Guro E. Lind,
Ragnhild A. Lothe

Published: September 1, 2011
https://doi.org/10.1371/journal.pone.0024419

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DNA methylation
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Gene expression
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Colon
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Signaling networks
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