PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes

Chia-Yen C. Wu; Zhiheng Jia; Wei Wang; Lisa M. Ballou; Ya-Ping Jiang; Biyi Chen; Richard T. Mathias; Ira S. Cohen; Long-Sheng Song; Emilia Entcheva; Richard Z. Lin

doi:10.1371/journal.pone.0024404

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Open Access

Peer-reviewed

Research Article

PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes

Chia-Yen C. Wu,

Affiliation Department of Physiology and Biophysics and Institute of Molecular Cardiology, Stony Brook University, Stony Brook, New York, United States of America
⨯
Zhiheng Jia,

Affiliation Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, United States of America
⨯
Wei Wang,

Affiliation Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Lisa M. Ballou,

Affiliation Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America
⨯
Ya-Ping Jiang,

Affiliation Department of Physiology and Biophysics and Institute of Molecular Cardiology, Stony Brook University, Stony Brook, New York, United States of America
⨯
Biyi Chen,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
Richard T. Mathias,

Affiliation Department of Physiology and Biophysics and Institute of Molecular Cardiology, Stony Brook University, Stony Brook, New York, United States of America
⨯
Ira S. Cohen,

Affiliation Department of Physiology and Biophysics and Institute of Molecular Cardiology, Stony Brook University, Stony Brook, New York, United States of America
⨯
Long-Sheng Song,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
Emilia Entcheva,

Affiliation Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, United States of America
⨯
Richard Z. Lin

* E-mail: richard.lin@sunysb.edu

Affiliations Department of Physiology and Biophysics and Institute of Molecular Cardiology, Stony Brook University, Stony Brook, New York, United States of America, Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Department of Veterans Affairs Medical Center, Northport, New York, United States of America
⨯

PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes

Chia-Yen C. Wu,
Zhiheng Jia,
Wei Wang,
Lisa M. Ballou,
Ya-Ping Jiang,
Biyi Chen,
Richard T. Mathias,
Ira S. Cohen,
Long-Sheng Song,
Emilia Entcheva

Published: September 2, 2011
https://doi.org/10.1371/journal.pone.0024404

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