Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice

Bin Feng; Ping Jiao; Yaohui Nie; Thomas Kim; Dale Jun; Nico van Rooijen; Zaiqing Yang; Haiyan Xu

doi:10.1371/journal.pone.0024358

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Peer-reviewed

Research Article

Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice

Bin Feng,

Affiliations Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China, Alpert Medical School, Hallett Center for Diabetes and Endocrinology, Brown University, Providence, Rhode Island, United States of America
⨯
Ping Jiao,

Affiliation Alpert Medical School, Hallett Center for Diabetes and Endocrinology, Brown University, Providence, Rhode Island, United States of America
⨯
Yaohui Nie,

Affiliation Alpert Medical School, Hallett Center for Diabetes and Endocrinology, Brown University, Providence, Rhode Island, United States of America
⨯
Thomas Kim,

Affiliation Alpert Medical School, Hallett Center for Diabetes and Endocrinology, Brown University, Providence, Rhode Island, United States of America
⨯
Dale Jun,

Affiliation Alpert Medical School, Hallett Center for Diabetes and Endocrinology, Brown University, Providence, Rhode Island, United States of America
⨯
Nico van Rooijen,

Affiliation Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
⨯
Zaiqing Yang,

Affiliation Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
⨯
Haiyan Xu

* E-mail: HXu@Lifespan.org

Affiliation Alpert Medical School, Hallett Center for Diabetes and Endocrinology, Brown University, Providence, Rhode Island, United States of America
⨯

Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice

Bin Feng,
Ping Jiao,
Yaohui Nie,
Thomas Kim,
Dale Jun,
Nico van Rooijen,
Zaiqing Yang,
Haiyan Xu

Published: September 12, 2011
https://doi.org/10.1371/journal.pone.0024358

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Liposomes
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Macrophages
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Adipose tissue
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Insulin
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Obesity
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Adiponectin
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Adipocytes
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