Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1G93A Mouse Model of ALS and Is Harmful in Female Mice

Open Access

Peer-reviewed

Research Article

Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1^G93A Mouse Model of ALS and Is Harmful in Female Mice

Hannah M. Kaneb,

Affiliations Wolfson Neuroscience Laboratories, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom, Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
⨯
Paul S. Sharp,

Affiliations Wolfson Neuroscience Laboratories, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom, Academic Neurology Unit, Sheffield Institute for Translational Neuroscience, Sheffield University, Sheffield, United Kingdom
⨯
Nazanin Rahmani-Kondori,

Affiliations Wolfson Neuroscience Laboratories, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom, Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
⨯
Dominic J. Wells

* E-mail: dwells@rvc.ac.uk

Affiliation Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
⨯

Body weight
Is the Subject Area "Body weight" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Muscle electrophysiology
Is the Subject Area "Muscle electrophysiology" applicable to this article?

Thanks for your feedback.
Amyotrophic lateral sclerosis
Is the Subject Area "Amyotrophic lateral sclerosis" applicable to this article?

Thanks for your feedback.
Motor neurons
Is the Subject Area "Motor neurons" applicable to this article?

Thanks for your feedback.
Water resources
Is the Subject Area "Water resources" applicable to this article?

Thanks for your feedback.
Diabetes mellitus
Is the Subject Area "Diabetes mellitus" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.