Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect

Open Access

Peer-reviewed

Research Article

Minsuh Seo,

Affiliation Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Jeong-Do Kim,

Affiliation Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
David Neau,

Affiliation Northeastern Collaborative Access Team, Cornell University, Argonne, Illinois, United States of America
⨯
Inder Sehgal,

Affiliation Department of Comparative Biomedical Science, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Yong-Hwan Lee

* E-mail: yhlee@lsu.edu

Affiliation Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯

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Apoptosis
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Hydrogen bonding
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Glycolysis
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Crystal structure
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Cancers and neoplasms
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HeLa cells
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Prostate cancer
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Protein interactions
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