Lys98 Substitution in Human AP Endonuclease 1 Affects the Kinetic Mechanism of Enzyme Action in Base Excision and Nucleotide Incision Repair Pathways

Open Access

Peer-reviewed

Research Article

Nadezhda A. Timofeyeva,

Affiliation Siberian Branch of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
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Vladimir V. Koval,

Affiliation Siberian Branch of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
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Alexander A. Ishchenko,

Affiliation CNRS UMR8200 Université Paris-Sud XI, Institut de Cancérologie Gustave Roussy, Villejuif, France
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Murat K. Saparbaev,

Affiliation CNRS UMR8200 Université Paris-Sud XI, Institut de Cancérologie Gustave Roussy, Villejuif, France
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Olga S. Fedorova

* E-mail: fedorova@niboch.nsc.ru

Affiliation Siberian Branch of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
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Near-infrared spectroscopy
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Isomerization
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Enzyme kinetics
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Substitution mutation
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Alanine
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Enzymes
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Hydrolysis
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Nucleotides
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