Laforin, a Dual Specificity Phosphatase Involved in Lafora Disease, Is Present Mainly as Monomeric Form with Full Phosphatase Activity

Vikas V. Dukhande; Devin M. Rogers; Carlos Romá-Mateo; Jordi Donderis; Alberto Marina; Adam O. Taylor; Pascual Sanz; Matthew S. Gentry

doi:10.1371/journal.pone.0024040

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Research Article

Laforin, a Dual Specificity Phosphatase Involved in Lafora Disease, Is Present Mainly as Monomeric Form with Full Phosphatase Activity

Vikas V. Dukhande,

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Devin M. Rogers,

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Carlos Romá-Mateo,

Affiliation Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain
⨯
Jordi Donderis,

Affiliation Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain
⨯
Alberto Marina,

Affiliation Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain
⨯
Adam O. Taylor,

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Pascual Sanz ,

* E-mail: sanz@ibv.csic.es (PS); matthew.gentry@uky.edu (MG)

Affiliation Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain
⨯
Matthew S. Gentry

* E-mail: sanz@ibv.csic.es (PS); matthew.gentry@uky.edu (MG)

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯

Laforin, a Dual Specificity Phosphatase Involved in Lafora Disease, Is Present Mainly as Monomeric Form with Full Phosphatase Activity

Vikas V. Dukhande,
Devin M. Rogers,
Carlos Romá-Mateo,
Jordi Donderis,
Alberto Marina,
Adam O. Taylor,
Pascual Sanz,
Matthew S. Gentry

Published: August 26, 2011
https://doi.org/10.1371/journal.pone.0024040

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